The Belly of The Beast
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02-12-2011, 10:40 PM
Join Date: Dec 2004
Calorie restriction increases the life span of many organisms, from yeast to mammals. In yeast, the life span gene affected by calorie restriction is Sir2 (silent information regulator 2). In mammals, Sirt1, an or-tholog of Sir2, controls the metabolism of white adipose tissue. Calorie restriction activates Sirt1, and the expressed Sirt1 protein inhibits the action of peroxy-some proliferator-activator receptor gamma (PPARy), the nuclear receptor that promotes adipogenesis. The effect is lipolysis and loss of fat. Lowering of adiposity appears to be one mechanism whereby calorie restriction affects life span.
more interesting stuff here - time to CRON out.
Last edited by LORD NOSE; 11-17-2011 at
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