New England just has too much firepower for Jax.
In order to beat New England, you really have to control both lines of scrimmage. I know analysts say that about every game, but against a team with their talent, this is probably moreso a truth.
But in doing so, you can't attempt to outscore them, you have to shorten the game and convert on big third downs.
You also have to play the field position game and get good special teams play. You will give up some plays but the key is to make them earn everything they get.
Get pressure on Brady and stuff the run...D-Line play.
I actually think SD is better suited for pulling off the uspet than Indy.